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In a study in subjects with moderate hepatic impairment (Child-Pugh class B), the plasma concentrations of free paliperidone were similar to those of healthy subjects, although total paliperidone exposure decreased because of a decrease in protein binding.

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No dosage adjustment required in patients with mild to moderate hepatic impairment (Child-Pugh class A and B); not studied in patients with severe hepatic impairment.

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Each dose of paliperidone palmitate is equivalent to a specific dose of paliperidone (39 mg, 78 mg, 117 mg, 156 mg and 234 mg of paliperidone palmitate is equivalent to 25 mg, 50 mg, 75 mg, 100 mg and 150 mg of paliperidone, respectively).

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Lumbar drainage: Caregivers use a needle to insert a catheter (tube) to drain CSF from around your spine for up to 5 days.

Every type of medication used to treat bipolar disorder, schizophrenia and autism spectrum disorders carries side effects and risks.

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The clinical information represents the expertise and practical knowledge of top physicians and pharmacists from leading academic medical centers in the United States and worldwide.

PORT (see Antipsychotic Pharmacotherapy) also provides a detailed review of psychosocial interventions.

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If you miss a dose, take it as soon as you remember.

There seems to be a cigarette smoke-exposure-dependent risk for TD in antipsychotic-treated patients.

Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 6-week placebo-controlled studies.

This condition can also develop after a short period of treatment at low doses but this is less common.

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Monthly maintenance doses can be administered in either the deltoid or gluteal muscle.

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The long-acting injection form of paliperidone is administered twice in the first 8 days of treatment, then every 4 weeks.

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One of the serious of two atypical antipsychotic medications, Risperdal and Invega, is the development of abnormally large breasts in boys and young males.

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Take this medication regularly to get the most benefit from it.

See the end of this Patient Information leaflet for a complete list of ingredients in Invega Sustenna.

Invega (paliperidone) is an antipsychotic medication that works by altering the effects of the chemicals in the brain.

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High-potency typical antipsychotics tend to cause more problems with extrapyramidal symptoms and increased prolactin levels than low-potency drugs.

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Hyperglycemia and Diabetes Mellitus: Hyperglycemia and diabetes mellitus, in some cases extreme and associated with ketoacidosis, hyperosmolar coma or death, have been reported in patients treated with all atypical antipsychotics (APS).

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This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995, including regarding product development.

Pediatric Use: safety and effectiveness not established in patients less than 18 years of age.

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According to data from the first randomized trial of cognitive therapy as a standalone therapy for schizophrenia, structured treatment with a therapist significantly reduced the severity of psychiatric symptoms and improved personal and social functioning and some dimensions of delusional beliefs and voice hearing.

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Invega Sustenna may rarely cause a prolonged (eg, more than 4 hours) or painful erection.

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Patients with risk factors for diabetes mellitus who are starting treatment with risperidone should undergo fasting blood glucose testing at the beginning of and periodically during treatment.

More than two of five (44%) underinsured adults reported not getting needed care because of cost in the past year, including not going to the doctor when sick, not filling a prescription, skipping a test or treatment recommended by a doctor, or not seeing a specialist (Exhibit 10, Table 6).

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The approval is based on two international, randomized, double-blind, placebo-controlled studies of patients with an established diagnosis of schizoaffective disorder, who were experiencing acute symptoms.

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